Arginine was isolated from a lupin seedling in 1886, but it wasn t until 1932 that scientists linked it to the creation of urea, the waste product necessary to remove toxic ammonia from the body. Several years later, researchers also discovered L-arginine was needed to make creatine the chemical important to muscle contractions and performance during exercise. Arginine is considered a semi-essential amino acid because the body can produce it but supplementation is sometimes still needed. People with protein malnutrition or other nutrition concerns may not have enough. A sufficient quantity of arginine is especially important in the diets of children, especially those experiencing growth. It is also involved in ammonia detoxification and immune function.
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