PPAR-beta/delta: novo alvo no tratamento da Síndrome Metabólica: Perspectivas sobre o agonista GW501516 (Portuguese Edition)

Product Code: 52803143
Product weight: 0.51 Pounds

Price: Rs:26839.00/-

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Description

A superativação do eixo ECA/AT1r está intimamente relacionada à Síndrome Metabólica e inflamação. A administração de frutose tem sido usada como um modelo para a indução da superatividade desse eixo e para o estudo das vias inflamatórias relacionadas ao AT1r. O objetivo do trabalho foi avaliar se a administração de um agonista PPAR-beta/delta poderia diminuir a superativação do eixo ECA/AT1r e consequentemente diminuir os danos causados pela dieta rica em frutose. Para isso foram utilizados camundongos machos que receberam uma dieta contendo 47% de frutose durante oito semanas ou uma dieta controle. Após oito semanas, os grupos foram redivididos para o início da administração do agonista durante três semanas. Os animais tratados apresentaram diversas melhoras nos parâmetros metabólicos e inflamatórios avaliados no fígado, tecido adiposo branco e rins. Com esses resultados podemos concluir que a curta administração do GW501516 pôde aliviar os efeitos deletérios ocasionados pela dieta rica em frutose, podendo ser pensado como uma nova ferramenta terapêutica no tratamento da superativação do eixo ECA/AT1r.

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