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With help from his assistant and a carefree coed, a cigar-chomping genius tries to clone his dead wife.Exuding the charm and grace for which he seems to hold the patent, Peter O Toole plays Doctor Harry Wolper, a renowned research biologist whose pet project is to clone his sorely missed wife, dead now for 30 years. Assisting him in fine fashion are Meli (Mariel Hemingway), a self-proclaimed 19-year-old nymphomaniac bent on capturing the affections of Dr. Wolper, and a research assistant (Vincent Spano), whose love interest is fellow student Virgina Madsen. This sweet and enjoyable romantic comedy is brought to a head when the Madsen character drops suddenly into a coma. Then Wolper s nemesis, played almost lovably by David Ogden Stiers, thwarts his cloning attempts by reclaiming the stolen equipment he s using to do so. While Dr. Wolper preaches the beauty of The Big Picture as a way of apprehending life, this one is decidedly a small picture, but in the sense of being attuned to small details, probably owing to the foreign sensibilities of Czech director Ivan Passer (Cutter s Way). The many disparate plot threads are eventually brought into harmony, though the sheer number of them may seem a jumble to many viewers. Better to let the big picture take care of itself, and content oneself with the many smaller pleasures this delightful film affords. --Jim Gay