Esta obra apresenta os resultados de uma pesquisa envolvendo a redução das concentrações de cálcio no interior do núcleo de células tumorais e como essa baixa na concentração afeta a expressão de moléculas chaves na sinalização para proliferação celular tais como ADAM-17 e EGFR, normalmente superexpressados em carcinoma de células escamosas. A associação de terapia gênica que reduz as concentrações de cálcio nuclear e radioterapia apresentam perspectivas promissoras para o tratamento de tumores do trato aerodigestivo superior, resistentes á radioterapia.
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