Yohimbine has been popular as of late as a fat loss supplement Specifically, research show that yohimbine can accelerate fat loss in stubborn areas. Sounds too good to be true of course, but there s actually scientific evidence to back this claim up. Well, yohimbine is a mild stimulant and can help suppress appetite, but there s more to its fat-burning properties. in simple terms. fat cells have receptors for catecholamines and that the primary catecholamines involved here are adrenaline and noradrenaline. Well, fat cells actually have two types of receptors for these chemicals: * Alpha receptors * Beta receptors And these receptors operate very differently. The physiology is quite complex, but what you need to know is when catecholamines bind to beta receptors, fat cells mobilize for burning. When the chemicals bind to alpha receptors, however, the cells don t mobilize. That is, in terms of fat loss, beta receptors are the heroes and alpha receptors are the villains. Furthermore, some adipose tissue (fat) in the body contains higher levels of alpha receptors than others, which makes it more resistant to mobilization than other fat deposits. This is the "stubborn fat" that people complain about and helps explain why it s so hard to lose those last few pounds in your lower abs (most guys) or hips and thighs (most girls). Enter yohimbine. This sneaky little molecule has a high affinity for alpha receptors, which means it binds to them more easily than beta receptors. Once yohimbine has bound with a fat cell, it "turns off" the alpha receptor, in a sense, which allows the catecholamines in your blood to bind to beta receptors instead. In other words, yohimbine prevents your fat cells alpha receptors from preventing fat loss particularly in stubborn areas.
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